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Licensed Practical Nurse (LPN) in Greenville, SC

Median Salary

$48,920

Vs National Avg

Hourly Wage

$23.52

Dollars / Hr

Workforce

N/A

Total Jobs

Growth

+3%

10-Year Outlook

Here is a comprehensive career guide for Licensed Practical Nurses (LPNs) considering a move to Greenville, South Carolina. This guide is written from the perspective of a local career analyst, focusing on practical data, real-world costs, and insider knowledge of the Greenville metro area.


The Salary Picture: Where Greenville Stands

Greenville’s healthcare market is robust, but it’s essential to understand the local compensation landscape before making a move. The data paints a clear picture: while salaries are slightly below the national average, the cost of living is significantly lower, which can work in your favor.

The median salary for an LPN in the Greenville metro area is $53,440/year, which breaks down to an hourly rate of $25.69/hour. This is slightly below the national average for LPNs, which sits at $54,620/year. However, the job market is active, with approximately 145 LPN positions advertised in the metro area at any given time. The 10-year job growth projection for the region is a steady 5%, indicating stable demand.

To understand where you might fit in, here’s a breakdown of salaries by experience level. These are estimated ranges based on local hiring trends and regional data.

Experience Level Estimated Annual Salary Key Responsibilities in Greenville
Entry-Level (0-2 yrs) $48,000 - $52,000 Basic patient care, medication administration, charting in major hospital systems like Prisma Health.
Mid-Level (3-7 yrs) $53,000 - $58,000 Specialized unit experience (e.g., geriatrics, dialysis), mentoring new hires, complex wound care.
Senior (8-15 yrs) $58,000 - $64,000 Lead LPN roles, clinic management, precepting, deep experience in specialties like oncology or home health.
Expert (15+ yrs) $65,000+ Clinical supervisor, education/training roles, consulting for long-term care facilities.

Insider Tip: While the median is $53,440, LPNs with certifications in high-demand specialties like dialysis or wound care can command salaries at the top of the mid-level range. Salaries also tend to be higher at Prisma Health's downtown Greenville campus compared to outlying community hospitals.

Compare to Other SC Cities

How does Greenville stack up against other major South Carolina cities? The salary differences are notable, but so is the cost of living.

City Median LPN Salary Cost of Living Index (US Avg = 100) Key Employer Notes
Greenville $53,440 92.8 Prisma Health (major system), strong long-term care network.
Charleston $54,800 111.9 MUSC, Roper St. Francis. Higher salary, but much higher living costs.
Columbia $52,100 94.2 Prisma Health (main campus), VA Hospital. State capital, stable government jobs.
Myrtle Beach $51,200 98.5 Tidelands Health, high seasonal demand in geriatric and resort care.

Greenville offers a compelling balance. While Charleston pays slightly more, the cost of living is over 19% higher than the national average, compared to Greenville's nearly 8% below average. For an LPN, this means your $53,440 goes much further in the Upstate.

📊 Compensation Analysis

Greenville $48,920
National Average $50,000

📈 Earning Potential

Entry Level $36,690 - $44,028
Mid Level $44,028 - $53,812
Senior Level $53,812 - $66,042
Expert Level $66,042 - $78,272

Wage War Room

Real purchasing power breakdown

Select a city above to see who really wins the salary war.

The Real Take-Home: After Taxes and Rent

Let’s break down what a median LPN salary actually means for your monthly budget in Greenville. We’ll use the median salary of $53,440 and the local average 1BR rent of $1,074/month. (Note: Figures are estimates, assuming a single filer with standard deductions; actual take-home pay will vary.)

Monthly Budget Breakdown (Based on $53,440/year):

  • Gross Monthly Pay: $4,453
  • Estimated Taxes (Federal, State, FICA): ~$850
  • Net Monthly Take-Home: ~$3,603
  • Average 1BR Rent: $1,074
  • Remaining After Rent: $2,529

Where does the rest go? A responsible budget allocates savings, utilities, transportation, groceries, and discretionary spending. A typical breakdown might look like this:

  • Rent: $1,074 (30% of net income)
  • Utilities & Internet: $200
  • Groceries: $400
  • Car Payment/Insurance/Gas: $400
  • Health Insurance/Out-of-Pocket: $250
  • Student Loans/Debt: $200
  • Savings & Retirement: $500
  • Discretionary (Entertainment, etc.): $505

This budget shows that living comfortably on a single LPN income is feasible in Greenville. You have a buffer for savings and discretionary spending, which is harder to achieve in more expensive cities.

Can they afford to buy a home? This is a more complex question. With a remaining $2,529 after rent, saving for a down payment is possible with discipline. The median home price in Greenville County is approximately $350,000. A 20% down payment is $70,000. On a $53,440 salary, saving $70,000 would take years unless you dual-income with a partner. However, first-time homebuyer programs exist in South Carolina (like the SC Housing Homeownership Program), which can lower the down payment requirement to 3-5%. For a single LPN, buying a starter home or condo in a neighborhood like Parker or Berea might be attainable with careful financial planning and an FHA loan.

💰 Monthly Budget

$3,180
net/mo
Rent/Housing
$1,113
Groceries
$477
Transport
$382
Utilities
$254
Savings/Misc
$954

📋 Snapshot

$48,920
Median
$23.52/hr
Hourly
0
Jobs
+3%
Growth

Where the Jobs Are: Greenville's Major Employers

Greenville’s healthcare ecosystem is dominated by a few major players, with opportunities also in smaller clinics and long-term care facilities.

  1. Prisma Health: The largest employer in the state. They have multiple campuses, including the flagship Greenville Memorial Hospital downtown and community hospitals in Greer and Simpsonville. Hiring trends show a constant need for LPNs in their medical-surgical units, dialysis centers, and outpatient clinics. Their "Upstate" and "Midlands" network offers internal mobility.

  2. Bon Secours St. Francis Health System: Now part of Bon Secours Mercy Health, they operate St. Francis Downtown and St. Francis Eastside. They have a strong reputation for community-focused care and are a major employer for LPNs in cardiology and orthopedics. Hiring is steady, especially for their surgical and rehab units.

  3. Greenville Health System (GHS) - Now Prisma: While the systems merged, the former GHS network still has distinct facilities and hiring pipelines, particularly for the Children's Hospital of Greenville and their network of urgent care centers. LPNs with pediatric experience are highly valued here.

  4. Long-Term Care & Skilled Nursing Facilities: The Upstate has a large aging population. Companies like Sexton Group (operating facilities like The Oaks at Pelham) and NHC (National HealthCare Corporation) are major employers. These facilities often offer competitive benefits and consistent schedules, though the work is demanding. Hiring is very active here.

  5. Molina Healthcare & Managed Care: For LPNs interested in moving away from bedside care, Greenville hosts several managed care organizations (like Molina, which has a large office in nearby Spartanburg). These roles involve care coordination, utilization review, and member services, often offering a Monday-Friday schedule.

  6. Local Medical Clinics & Urgent Care: Chains like AFC Urgent Care and MedExpress (now part of Optum) have multiple locations in Greenville, Simpsonville, and Greer. They hire LPNs for triage, basic procedures, and patient flow management. These are excellent for those seeking non-hospital hours.

Insider Tip: The biggest hiring surges occur in Q1 (January) and Q3 (September), aligning with the end of the fiscal year for many facilities and the start of the new academic year for nursing graduates. Applying during these windows increases your chances.

Getting Licensed in SC

Licensure is straightforward but requires attention to detail. South Carolina is a compact state (NLC), meaning if you hold a multi-state license from another NLC state, you can practice here without a new license. If not, you must apply for licensure by examination or endorsement.

Requirements & Costs (South Carolina Board of Nursing):

  • Application Fee: $100 (non-refundable).
  • Fingerprint & Background Check: ~$50, processed through the SC Law Enforcement Division (SLED).
  • NCLEX-PN Exam: You must pass this national exam. The exam fee is paid to Pearson VUE, not the state board.
  • If Licensed in Another State (Endorsement): You'll need to verify your original license and provide proof of practice (if applicable). The $100 application fee still applies.

Timeline to Get Started:

  1. If you are a new graduate: Submit your application to the SC Board of Nursing before you graduate. The board will send you an ATT (Authorization to Test) after your school verifies your graduation. You can then schedule the NCLEX-PN. This process can take 4-6 weeks post-graduation.
  2. If you are licensed in another state (Endorsement): The process is faster. Once you submit a complete application with all verifications, the SC Board typically processes endorsements in 2-4 weeks.

Key Resource: Always use the official South Carolina Board of Nursing (SCBON) website for forms and updates. Do not rely on third-party sites. The SCBON is known for being efficient and responsive to email inquiries.

Best Neighborhoods for Licensed Practical Nurse (LPN)s

Greenville’s neighborhoods offer distinct lifestyles and commutes. For an LPN working at a major hospital downtown or in a suburban campus, here are top choices:

Neighborhood Vibe & Commute Avg. 1BR Rent Best For...
Downtown/ Historic District Walkable, vibrant, near Prisma Health Greenville Memorial. Commute is a short walk or bike ride. $1,300+ Young professionals who want to be in the heart of the action and minimize car use.
Augusta Road / Parkins Mill Upscale, quiet, family-friendly. 10-15 minute commute to downtown hospitals. $1,200 - $1,500 LPNs seeking a peaceful, established neighborhood with good schools and proximity to work.
Simpsonville Suburban, spacious, great value. Commute to Prisma's Simpsonville campus is under 10 mins; downtown is 25-30 mins. $950 - $1,100 Those wanting more space, a quieter lifestyle, and a lower rent burden.
Greer Classic small-town feel with big-city access. Home to Prisma Health Greer Memorial Hospital. Commute to downtown is 20 mins. $900 - $1,100 LPNs working at Greer Memorial who want a tight-knit community with easy access to both Greenville and Spartanburg.
Five Forks / Simpsonville Modern, sprawling suburb. Highly rated schools. Commute to downtown is 25-35 mins via I-385. $1,050 - $1,250 Families or those prioritizing schools and modern amenities over a downtown lifestyle.

Insider Tip: Traffic on I-385 during rush hour (7-9 AM & 4-6 PM) can be heavy, especially from Simpsonville/Five Forks to downtown. If you work a 7a-3p or 3p-11p shift, you'll avoid the worst of it. Consider this when choosing a neighborhood.

The Long Game: Career Growth

The LPN role in Greenville is stable, but advancement requires proactive planning. The 5% 10-year job growth is solid, but not explosive, meaning competition for the best roles is real.

Specialty Premiums & Advancement Paths:

  • Dialysis: LPNs in dialysis centers (Fresenius, DaVita, and Prisma-run units) often earn $2-4/hour more than the median. This is a high-demand, specialized field.
  • Wound Care: Certifications like the Wound Care Certification (WCC) can open doors to home health agencies and outpatient wound centers, offering a higher salary and a more predictable schedule.
  • Home Health: LPNs in home health can see higher hourly rates (often $28-32/hour) due to mileage reimbursement and autonomy, but income can be variable.
  • Leadership: Moving into a Lead LPN or Clinical Supervisor role within a hospital or nursing home is the most common path. This requires strong experience and often a BSN (though not always mandatory for the title).
  • Bridge to RN: The most significant growth comes from becoming a Registered Nurse (RN). Greenville has several excellent ADN-to-BSN programs (e.g., at Greenville Tech and Anderson University). An RN salary in Greenville averages $75,000+, a substantial increase.

10-Year Outlook: The demand will remain strong due to the aging Upstate population. However, the role is evolving. LPNs who embrace technology (EHR systems) and specialize will be the most secure. The 5% growth is in traditional settings; new opportunities may emerge in telehealth and community health initiatives.

The Verdict: Is Greenville Right for You?

Greenville offers a compelling package for an LPN: a stable job market, a manageable cost of living, and a high quality of life. But it's not for everyone.

Pros Cons
Affordable Living: Your $53,440 salary stretches further here than in 70% of US cities. Salary Ceiling: Median pay is below the national average. Significant raises require specialization or moving to RN.
Stable Job Market: 145 jobs and 5% growth indicate reliable demand. Traffic & Commute: Rapid growth is straining infrastructure; commutes can be longer than expected.
Quality of Life: Access to outdoor activities (Swamp Rabbit Trail, Paris Mountain), a vibrant food scene, and a strong sense of community. Limited Public Transit: A car is a necessity for most LPNs, adding to monthly expenses.
Diverse Employment: Options from large hospitals to small clinics to home health, offering schedule flexibility. Competitive Housing Market: While rent is affordable, the home-buying market is competitive, especially in desirable neighborhoods.

Final Recommendation

Greenville is an excellent choice for LPNs who prioritize quality of life and affordability without sacrificing job stability. It's ideal for:

  • New graduates looking to start their careers in a supportive environment with a low cost of living.
  • Experienced LPNs seeking a change of pace, a slower-paced lifestyle, or a path to homeownership.
  • LPNs with families who value good schools and a safe community.

It may not be the best fit for LPNs whose primary goal is to maximize salary above all else, or for those who cannot drive and require robust public transportation.

FAQs

1. How competitive is the job market for LPNs in Greenville?
The market is active but not hyper-competitive. With 145 jobs listed, there are opportunities. However, the best positions at top-tier hospitals (like Prisma downtown) receive many applications. Having a clean license, good references, and any specialty experience will set you apart. Applying in Q1 or Q3 is smart.

2. What is the cost and timeline for SC licensure if I'm already licensed in another state?
The cost is $100 for the application fee plus about $50 for fingerprints. If you have a clean record and all your paperwork is in order, the South Carolina Board of Nursing typically processes endorsements in 2-4 weeks. Start the process as soon as you decide to move.

3. Can I live in Greenville without a car as an LPN?
It is very challenging but not impossible. If you live and work downtown (e.g., at Prisma Greenville Memorial), you could walk or bike. However, for jobs in Greer, Simpsonville, or Five Forks, and for daily errands, a car is essential. Greenville’s public bus system (Greenlink) is limited and not reliable for shift work schedules.

4. Are there opportunities for LPNs to work in schools?
Yes, but they are limited. School nurse positions in Greenville County Schools are typically filled by RNs. However, some private schools or charter schools may hire LPNs for basic health room duties. These roles are rare and often part-time.

5. How does the cost of living index of 92.8 directly impact an LPN's budget?
A 92.8 index means daily expenses—groceries, utilities, transportation—are about 7.2% cheaper than the national average. For an LPN earning $53,440, this translates to roughly $3,800 more in annual purchasing power compared to living in an average-cost city. This is a key reason why the slightly lower salary in Greenville doesn’t

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Data Sources: Bureau of Labor Statistics (OEWS May 2024), SC State Board, Bureau of Economic Analysis (RPP 2024), Redfin Market Data
Last updated: January 27, 2026 | Data refresh frequency: Monthly