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Registered Nurse in Sioux Falls, SD

Comprehensive guide to registered nurse salaries in Sioux Falls, SD. Sioux Falls registered nurses earn $83,565 median. Compare to national average, see take-home pay, top employers, and best neighborhoods.

Median Salary

$83,565

Vs National Avg

Hourly Wage

$40.18

Dollars / Hr

Workforce

1.9k

Total Jobs

Growth

+6%

10-Year Outlook

The Salary Picture: Where Sioux Falls Stands

As a career analyst who’s lived in Sioux Falls for years, I can tell you the nursing salary here is a solid middle-ground play. It’s not the explosive growth you’d see in a coastal metro, but it’s stable, predictable, and backed by a strong healthcare ecosystem. The median salary for Registered Nurses in Sioux Falls is $83,565/year, which breaks down to an hourly rate of $40.18/hour. That’s slightly below the national average of $86,070/year, but don’t let that number fool you. When you factor in South Dakota’s lack of state income tax and a cost of living that’s 9.7% below the national average, your purchasing power here is significantly higher than in most states.

Sioux Falls is the undisputed healthcare hub of the state. With a metro population of 206,405 and 1,857 nursing jobs in the metro area, demand is consistent. The 10-year job growth is projected at 6%, which aligns with national trends but is fueled locally by an aging population and the expansion of the Avera and Sanford health systems. For context, while a nurse in Rapid City might see a similar median salary ($84,200), the job market is smaller and more seasonal. In contrast, a nurse in Aberdeen would likely earn less (closer to $78,000) with fewer specialty opportunities.

Here’s a realistic experience-level breakdown for Sioux Falls:

Experience Level Typical Role Annual Salary Range (Sioux Falls) Key Responsibilities
Entry-Level (0-2 yrs) Med-Surg, New Grad Residency $68,000 - $76,000 Direct patient care, medication administration, basic assessments.
Mid-Level (3-7 yrs) Charge Nurse, ICU/ER, Outpatient $78,000 - $92,000 Specialized unit care, patient/family education, precepting.
Senior-Level (8-15 yrs) Clinical Nurse Specialist, Manager $90,000 - $105,000 Leadership, quality improvement, complex case management.
Expert (15+ yrs) Director, NP/PA, Unit Administrator $100,000+ Strategic oversight, policy development, system-level leadership.

Insider Tip: The starting salaries at the two big players—Sanford Health and Avera Health—are very competitive within the first three years. However, the largest salary jumps often come from moving into specialized units (like the Sanford USD Medical Center’s Level 1 Trauma Center) or pursuing a Master’s degree to become a Nurse Practitioner, which can push your salary well into the six-figure range.

šŸ“Š Compensation Analysis

Sioux Falls $83,565
National Average $86,070

šŸ“ˆ Earning Potential

Entry Level $62,674 - $75,209
Mid Level $75,209 - $91,922
Senior Level $91,922 - $112,813
Expert Level $112,813 - $133,704

Wage War Room

Real purchasing power breakdown

Select a city above to see who really wins the salary war.

The Real Take-Home: After Taxes and Rent

Let’s get down to the numbers that matter. With a median salary of $83,565 in a state with no income tax, your take-home pay is straightforward but must be weighed against local costs.

A single filer with standard deductions will see roughly $63,000-$65,000 after federal taxes, FICA (7.65%), and local sales taxes (Sioux Falls city sales tax is 2.0%, plus a 1.0% state tax, for a total of 6.5%). That leaves you with about $5,250 - $5,400 per month.

Now, let’s build a sample monthly budget. I’ll use the average 1BR rent of $884/month, but we’ll refine this by neighborhood later.

Expense Category Monthly Cost (Estimate) Notes
Rent (1BR Apt) $884 Average citywide. Can range from $750 to $1,200+
Utilities $150 Includes electric, gas, water, and trash (internet extra)
Groceries $350 Sioux Falls has competitive pricing at Hy-Vee and Walmart.
Car Payment/Insurance $400 Assumes a modest car payment + insurance (SD has low rates).
Gas $120 Commutes are generally short; gas is typically cheaper than national avg.
Health Insurance $250 Employer-sponsored plans are common and affordable.
Misc. (Entertainment, etc.) $400 Dining out, streaming, hobbies.
Total $2,554
Remaining for Savings/Debt ~$2,700 Strong for building emergency fund or paying off loans.

Can they afford to buy a home? Absolutely. The Sioux Falls housing market is one of the most accessible in the Midwest for professionals. The median home price is around $300,000. With a 20% down payment ($60,000) and a monthly mortgage of roughly $1,800 (including taxes/insurance), a nurse earning $83,565 would be well within the recommended 28-30% of gross income threshold. Building that down payment might take 2-3 years of disciplined saving, but the monthly payment on a mortgage is often comparable to or less than renting a larger space.

šŸ’° Monthly Budget

$5,432
net/mo
Rent/Housing
$1,901
Groceries
$815
Transport
$652
Utilities
$435
Savings/Misc
$1,630

šŸ“‹ Snapshot

$83,565
Median
$40.18/hr
Hourly
1,857
Jobs
+6%
Growth

Where the Jobs Are: Sioux Falls's Major Employers

The nursing job market here is dominated by two massive, competing health systems and a few key players. The hiring process is professional and structured, often requiring an interview with a panel.

  1. Sanford Health: The largest employer in the region. Their flagship Sanford USD Medical Center is a Level 1 Trauma Center and the teaching hospital for the University of South Dakota Sanford School of Medicine. They are constantly hiring for ER, ICU, OR, and pediatric specialties. Hiring trend: Aggressive growth in telehealth and specialty clinics outside the main hospital.
  2. Avera Health: The other titan, with Avera McKennan Hospital & University Health Center as its cornerstone. Avera has a strong focus on oncology, heart care, and women’s health. They are known for a slightly more community-focused culture. Hiring trend: Expansion of the Avera on Louise campus and urgent care centers.
  3. Sioux Falls Surgery Center: A large, independent ambulatory surgery center. Great for nurses who prefer a predictable M-F schedule without hospital weekends/holidays. Hiring trend: Steady, with a focus on experienced perioperative nurses.
  4. LifeScape: The primary provider for individuals with disabilities in the region. Offers roles in pediatric nursing, behavioral health, and residential support. Hiring trend: Growing due to increased state funding for community-based services.
  5. Sioux Falls Public Schools (SFSD): School nurse positions are competitive and offer a fantastic schedule (summers off, holidays). Requires a BSN and often prior experience. Hiring trend: Consistent, with openings tied to retirements.
  6. Local Urgent Care Chains (Carex, etc.): Multiple companies operate urgent care clinics. Ideal for nurses seeking autonomy and fast-paced, lower-acuity care. Hiring trend: High demand as they expand to suburban areas like Harrisburg and Tea.

Getting Licensed in SD

South Dakota is a Nurse Licensure Compact (NLC) state. This is a huge advantage. If you already have a multi-state license from another NLC state (which includes most of the Midwest), you can start working in Sioux Falls immediately and your license is valid here. The process is simple: you just need to update your primary state of residency to SD.

If you are not from a compact state, the process is straightforward but requires time.

Requirements & Process:

  1. Application: Submit an application through the South Dakota Board of Nursing website.
  2. Fingerprinting: Mandatory criminal background check. Cost: ~$50.
  3. NCLEX: If you’re a new grad, you must pass the NCLEX-RN. The board will send your eligibility to Pearson VUE.
  4. Fees: Application fee is $100. Initial licensing fee is $108.
  5. Timeline: From application submission to an active license can take 4-8 weeks if all documents are in order. Insider Tip: Start the process at least 3 months before your planned move. The board’s website is clear, but their customer service can be slow to respond. Be proactive.

Best Neighborhoods for Registered Nurses

Where you live in Sioux Falls dramatically impacts your commute and lifestyle. The city is spread out, but traffic is minimal.

Neighborhood Vibe & Commute 1BR Rent Estimate Best For...
Downtown Urban, walkable, vibrant nightlife. 5-10 min commute to Avera/Sanford. $950 - $1,400 Young professionals who want bars, restaurants, and events at their doorstep.
Southwest (41st St Corridor) Suburban, family-friendly, excellent schools. 10-15 min commute. $900 - $1,200 Nurses with families or those who prefer newer apartments and shopping proximity.
Southeast (Minnesota Ave) Established, quiet, wooded lots. 15-20 min commute to downtown hospitals. $800 - $1,000 Those seeking a more suburban feel with mature trees and larger yards.
Near the University (USD Medical School) Academic, energetic, mix of students and professionals. 5-10 min commute. $750 - $1,000 New grads who want to be close to the action and potential mentorship.
Harrisburg (Just South) Small-town feel, top-tier schools, very safe. 20-25 min commute. $850 - $1,100 Nurses looking for a quiet, community-focused life with a short drive to the city.

The Long Game: Career Growth

Sioux Falls is not a dead-end for your career. The growth is vertical and specialized.

  • Specialty Premiums: Moving into critical care (ICU, ER) can add a $5,000 - $10,000 premium to your base salary. Certified specialties like CCRN or CEN are highly valued. OR nurses also command higher pay due to the technical skill required.
  • Advancement Paths: The most common path is from bedside nurse to Charge Nurse (small pay bump, more responsibility) to Nurse Manager (significant bump, $95k+). A more lucrative path is obtaining a Master’s (MSN) to become a Nurse Practitioner (NP). NPs in Sioux Falls easily earn $110,000 - $130,000+, especially in primary care or specialties like cardiology at Avera or Sanford.
  • 10-Year Outlook: The 6% job growth is steady. The biggest opportunities will be in geriatrics (due to SD’s aging population), home health, and telehealth. Sanford and Avera are both investing heavily in remote monitoring and virtual care platforms, creating new non-bedside roles for tech-savvy nurses.

The Verdict: Is Sioux Falls Right for You?

Pros Cons
High purchasing power due to no state income tax and low cost of living (90.3 Index). Winters are harsh. Snow, ice, and cold from November to April. A reliable car with AWD is a must.
Stable, growing job market with two major health systems and low unemployment. Limited cultural diversity compared to larger coastal cities. Can feel homogeneous.
Short, manageable commutes (avg. 15-20 mins). Social scene can be quiet. Nightlife revolves around sports and bars; fewer niche cultural events.
Family-friendly with excellent public schools and safe suburbs. "Big small town" feel. The medical community is tight-knit; your professional and personal life may overlap.
Easy access to nature with the Big Sioux River and nearby state parks. Limited public transportation. You will need a car.

Final Recommendation: Sioux Falls is an ideal choice for a pragmatic, career-focused RN who values financial stability, a manageable workload, and a high quality of life. It’s particularly well-suited for nurses who are early in their careers (building savings) or those with families looking for a safe, affordable community with strong schools. If you’re seeking the fast-paced, anonymous energy of a major metropolis, you may find it slow. But if you want to be a respected member of a close-knit healthcare community while building real wealth, Sioux Falls is a hidden gem.

FAQs

Q: Is the cost of living really as low as they say?
A: Yes, but with nuances. Groceries, utilities, and housing are significantly cheaper. However, imported goods, new cars, and dining out are priced similarly to the national average. The lack of state income tax is the biggest financial win.

Q: How competitive are the nursing jobs here?
A: For experienced nurses, especially in ICU, ER, and OR, it’s a candidate’s market. Sanford and Avera will compete for you. For new grads, it’s competitive but not impossible. Insider Tip: Apply to the formal new grad residency programs at both Sanford and Avera. These are your best entry point and provide structured support.

Q: What’s the weather really like for someone from a warmer climate?
A: Be prepared for a real winter. You’ll need a winter coat, snow boots, and a car with good tires. Summers are beautiful and mild, but spring and fall can be unpredictable. The key is having a reliable vehicle and a heated garage if possible.

Q: Are there opportunities for part-time or flexible scheduling?
A: Yes, especially in outpatient clinics, urgent care, and home health. Hospitals offer various shifts (3x12s are standard), but part-time benefits are limited. Travel nursing within the region is also a viable option to diversify experience.

Q: Which hospital system is better to work for?
A: It’s a classic rivalry. Sanford is often seen as more research-focused, tech-forward, and with a larger scale. Avera is frequently described as having a warmer, more community-oriented culture. Both are excellent employers with comparable pay and benefits. The best fit depends on your preferred unit culture and career goals.


Data Sources: U.S. Bureau of Labor Statistics (BLS) Occupational Employment and Wage Statistics, South Dakota Department of Labor & Regulation, South Dakota Board of Nursing, Sioux Falls Chamber of Commerce, Zillow Rent Data, Council for Community and Economic Research (C2ER) Cost of Living Index.

Data Sources: Bureau of Labor Statistics (OEWS May 2024), SD State Board, Bureau of Economic Analysis (RPP 2024), Redfin Market Data
Last updated: January 28, 2026 | Data refresh frequency: Monthly